A new winter storm in the US—from the Midwest and up the Northeast Coast—has disrupted travel and canceled more than 2,000 flights Tuesday and Wednesday.

The National Weather Service is reporting possible accumulations of up to 10 in. of snow in the Washington DC region and up to 8 in. in the New York-New England area, after slamming Chicago Tuesday.

The Chicago Dept. of Aviation reported 850 flights canceled Tuesday at O’Hare Airport, and 225 cancellations at Midway.  As the storm moved east, over 400 flights were canceled at Philadelphia, New York JFK, LaGuardia and Newark airports, according to flight tracking service FlightStats.

At the Washington DC area airports—Baltimore Washington, Washington National and Dulles—750 flights had been canceled as of mid-afternoon, according to FlightStats. Wind gusts were expected to reach 40 mph.

By mid-afternoon Wednesday, US Airways reported delays at 27 airports and canceled 128 flights, according to FlightStats data. Delta Air Lines canceled 151 flights at 11 airports. At United Airlines, 189 flights were canceled at 37 airports.

ExpressJet canceled 273 flights, Republic Airlines, 135, Air Wisconsin, 160, Southwest Airlines and Pinnacle Airlines, 126 flights, FlightStats reported.